Senetek PLC

Industry: Pharmaceuticals, Biotechnology
ITEM 1—BUSINESS Overview Senetek PLC, together with its subsidiaries (the “Company” which may be referred to as “Senetek”, “we”, “us”, or “our”), is a public limited company organized under the laws of England in 1983 (registration number 1759068). Senetek has four wholly-owned subsidiaries, Senetek Drug Delivery Technologies Inc. (“SSDT”), Senetek Asia Limited (“HK”) and Senetek Denmark ApS, corporations formed by … ( www.senetekplc.com )

Senetek PLC
620 Airpark Rd
LONDON SW1E 5HW
United Kingdom

Amersham plc

Industry: Pharmaceuticals, Biotechnology
Amersham is a world leader in medical diagnostics and in life sciences. We employ 9,500 people around the world. Our shares are traded on the London, New York and Oslo stock exchanges (AHM), and we are listed on the FTSE Index of Britain’s 100 largest companies. Our company was formed in 1997 from the businesses of Amersham International (UK), Pharmacia Biotech (Sweden) and Nycomed (Norway). In 2001 the company changed its name to Amersham plc and our businesses became Amersham Biosciences and Amersham Health. Together we combine skills in understanding genetic predisposition and the molecular basis of disease, with those for screening for ( www.amersham.com )

Amersham plc
Amersham Place
Little Chalfont, Buckinghamshire HP7 9NA
United Kingdom

Tel: +44 1494 544000
Fax: +44 1494 542266

Oxford BioMedica plc

Industry: Pharmaceuticals, Biotechnology
Oxford BioMedica (LSE: OXB) is a biopharmaceutical company specialising in the development of novel gene-based therapeutics with a focus on oncology and neurotherapy. The Company was established in 1995 as a spin out from Oxford University, and is listed on the London Stock Exchange. Oxford BioMedica has core expertise in gene delivery, as well as in-house clinical, regulatory and manufacturing know-how. In oncology, the pipeline includes two clinical candidates and a preclinical targeted antibody therapy, which is being developed in collaboration with Wyeth. The Company has started Phase III development of its lead cancer immunotherapy product, TroVax, in renal cancer and has an ongoing Phase II programme in various cancer settings including renal, colorectal and prostate ( www.oxfordbiomedica.co.uk )

Oxford BioMedica plc
The Medawar Centre
Oxford, OXON Ox4 4ga
United Kingdom

Thiakis Limited

Industry: Drug Manufacturing, Pharmaceuticals, Biotechnology
Thiakis is a privately owned biopharmaceutical company founded in 2004; focused on the development of novel therapeutic approaches for the treatment of obesity and other metabolic diseases. ( www.thiakis.com )

Thiakis Limited
Bessemer Building (RSM) Prince Consort Road
London SW7 2BP
United Kingdom

Tel: +44 207 594 1059
Fax: +44 207 594 1070

GeneMedix plc

Industry: Drug Manufacturing, Pharmaceuticals, Biotechnology
GeneMedix is a UK based, globally focused biopharmaceutical company, specialising in the development and manufacture of cost effective treatments for some of the world’s most serious diseases. The strategy for GeneMedix continues to focus on commercialising a range of high quality, therapeutic proteins and initially launching in markets where patents have never existed, or have expired, in order to make such products available to a wider number of patients globally. ( www.genemedix.com )

GeneMedix plc
Rosalind Franklin House Fordham Road
Newmarket, CB8 7XN
United Kingdom

Tel: +44 1638 663320

Pharmexa

Industry: Drug Manufacturing, Pharmaceuticals, Biotechnology
Pharmexa is a leading biotech company in the field of active immunotherapy and vaccines for the treatment of cancer, serious chronic and infectious diseases. The company has been listed on the Copenhagen Stock Exchange since 2000. The Pharmexa group consists of GemVax AS, a Norwegian subsidiary, developing peptide vaccines for cancer and Pharmexa-Epimmune, a US subsidiary, focusing on T cell epitope-based vaccines for cancer and infectious diseases. ( www.pharmexa.com )

Pharmexa
Piper Jaffray Ltd. – Dr. Richard Parks & Dr. Sally Bennett 18 King William Street
London EC4N 7US
United Kingdom

Tel: +45 8922 2864

Syntopix Group plc

Industry: Drug Manufacturing, Pharmaceuticals, Biotechnology
Syntopix Group plc is a drug development company focused on prescription and over-the counter products for the treatment of common inflammatory skin conditions. Our vision is to become a world-class company providing clinical solutions for important dermatological diseases. This will be achieved by creating a continuous pipeline of novel products for the topical treatment and prevention of dermatological conditions, principally acne and staphylococcal infections including MRSA. The Syntopix strategy has been designed to reduce the risks and costs associated with drug discovery and development. We concentrate on change of use and combinations of known compounds with well-documented pharmacology and toxicity profiles that are already established as safe for human ( www.syntopix.com )

Syntopix Group plc
Leeds Innovation Building 103 Clarendon Road
Leeds, LS2 9DF
United Kingdom

Tel: +44 8451 259204
Fax: +44 8451 259205

Syntopix Group plc

Industry: Drug Manufacturing, Pharmaceuticals, Biotechnology
Syntopix Group plc is a drug development company focused on prescription and over-the counter products for the treatment of common inflammatory skin conditions. Our vision is to become a world-class company providing clinical solutions for important dermatological diseases. This will be achieved by creating a continuous pipeline of novel products for the topical treatment and prevention of dermatological conditions, principally acne and staphylococcal infections including MRSA. The Syntopix strategy has been designed to reduce the risks and costs associated with drug discovery and development. We concentrate on change of use and combinations of known compounds with well-documented pharmacology and toxicity profiles that are already established as safe for human ( www.syntopix.com )

Syntopix Group plc
Leeds Innovation Building 103 Clarendon Road
Leeds, LS2 9DF
United Kingdom

Tel: +44 8451 259204
Fax: +44 8451 259205

Hunter-Fleming Ltd

Industry: Drug Manufacturing, Pharmaceuticals, Biotechnology
Hunter-Fleming is a biopharmaceutical company developing new medicines to treat neurological and cardiovascular disorders. The company focus is on unmet patient needs in dementias such as Alzheimer’s disease, as well as other important conditions such as neuropathic pain, head and spinal cord injuries and myocardial infarction. ( www.hunter-fleming.com )

Hunter-Fleming Ltd
Regus House 1 Friary Temple Quay
Bristol BS1 6EA
United Kingdom

Tel: +44 117 900 8265
Fax: +44 117 900 8424

Curidium Limited

Industry: Drug Manufacturing, Pharmaceuticals, Biotechnology
Curidium is a drug discovery and development company focused on identifying targeted medicines to treat patients more effectively. Curidium has developed a novel and proprietary technology, Homomatrix®, to untangle the underlying mechanisms of human diseases. Curidium’s technology identifies different patient subpopulations each having a distinct disease mechanism. This enables the generation of new diagnostic tools and medicines designed for a subgroup of patients and potentially offering improved safety and effectiveness. Curidium is initially applying its core technology to diseases of the Central Nervous System. Curidium listed on the AIM of the London Stock Exchange on 6 July 2006 and trades under the symbol CUR. Recent News: 15 Dec 2006 ( www.curidium.com )

Curidium Limited
Hamilton House Mabledon Place
London WC1H 9BB
United Kingdom

Tel: +44 20 7554 8790