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Senetek PLC

Industry: Pharmaceuticals, Biotechnology
ITEM 1—BUSINESS Overview Senetek PLC, together with its subsidiaries (the “Company” which may be referred to as “Senetek”, “we”, “us”, or “our”), is a public limited company organized under the laws of England in 1983 (registration number 1759068). Senetek has four wholly-owned subsidiaries, Senetek Drug Delivery Technologies Inc. (“SSDT”), Senetek Asia Limited (“HK”) and Senetek Denmark ApS, corporations formed by … ( www.senetekplc.com )

Senetek PLC
620 Airpark Rd
LONDON SW1E 5HW
United Kingdom

DNA Sciences Inc

Industry: Pharmaceuticals, Biotechnology
DNA Sciences, Inc. is an integrated genetics discovery company focused on identifying the genetic basis of response to drug treatment, disease susceptibility and disease progression. The company has a staff of world-class scientists involved in a broad range of genetics activities extending from discovery and development to genetic testing services. DNA Sciences is also a leading provider of pharmacogenetic services to the pharmaceutical industry through its wholly-owned subsidiary, DNA Sciences Laboratories (formerly PPGx, Inc.). DNA Sciences is based in Fremont, Calif. and was founded in May 1998. ( www.dna.com )

DNA Sciences Inc
3500 Paramount Parkway
Morrisville, North Carolina 27560
USA

Tel: (919) 463-6705

Agencourt Bioscience Corporation

Industry: Pharmaceuticals, Biotechnology
Agencourt Bioscience Corporation is a provider of genomic services and nucleic acid purification products that help biotech and pharmaceutical companies improve the effectiveness and efficiency of their drug development pipelines. Agencourt’s Discovery SolutionsÔ suite of genomic and functional genomic services include high-throughput sequencing, SAGE sequencing, SNP discovery and genotyping. The company’s purification products and services are based on the proven and patented Solid Phase Reversible Immobilization (SPRIÔ) technology, which has been used to sequence over 20 billion base pairs of high-quality DNA or more than one-third of the human ( www.agencourt.com )

Agencourt Bioscience Corporation
500 Cummings Center Suite 2450
Beverly, Massachusetts 01915
USA

Tel: (978) 867-2600

Chronogen Inc.

Industry: Pharmaceuticals, Biotechnology
Chronogen Inc., a privately-held drug discovery company, is a leader in the identification of targets that control the degenerative processes of aging. Based on this innovative approach, the company is developing novel products to control lipid and oxidative stress levels, which are established disease mechanisms in cardiovascular disorders. The control of aging in whole model organisms has provided very valuable assets for a drug discovery technology that will lead to novel and efficacious drugs in significant markets including atherosclerosis, vascular complications of diabetes, and ischemia/reperfusion injuries. Chronogen is headquartered in Montreal, Canada. ( www.chronogen.com )

Chronogen Inc.
2901 Rachel E. Suite 22
Montreal, Quebec H1W 4A4
Canada

Tel: (514) 521-9595
Fax: (514) 521-1579

Paradigm Genetics , Inc.

Industry: Pharmaceuticals, Biotechnology
Paradigm Genetics is a biotechnology company applying its proprietary systems biology platform to the discovery of safer, more effective drugs and agrichemicals. Paradigm Genetics has major collaborations with the National Institute of Environmental Health Sciences, Bayer CropScience, the Monsanto Company, Pioneer Hi-Bred International, the National Institute of Standards & Technology’s Advanced Technology Program, and L’Oréal Inc. ( www.paradigmgenetics.com )

Paradigm Genetics , Inc.
Mail Stop P7 50
Richland, Washington 99352
USA

Transgene S.A.

Industry: Pharmaceuticals, Biotechnology
Transgene is a biopharmaceutical company dedicated to the discovery and development of gene-based therapeutic vaccines and immunotherapy products for the treatment of cancer and infectious diseases. ( www.transgene.fr )

Transgene S.A.
3656 Happy Valley Road
Lafayette, California 94549
USA

Tel: (925) 299-2959

The Jackson Laboratory

Industry: Pharmaceuticals, Biotechnology
The Jackson Laboratory, founded in 1929, is the world’s largest mammalian genetics research institution. Its research staff of more than 450 investigates the genetic basis of cancers, heart disease, osteoporosis, Alzheimer’s disease, glaucoma, diabetes, and many other human diseases and disorders. The Laboratory is also the world’s source for nearly 3,000 strains of genetically defined mice, home of the Mouse Genome Database and many other publicly available information resources, and an international hub for scientific courses, conferences, training and ( www.jax.org )

The Jackson Laboratory
600 Main Street
Bar Harbor, Maine 04609
USA

Tel: (207) 288-6051
Fax: (207) 288-6076

ICOS Corporation

Industry: Drug Manufacturing, Pharmaceuticals, Biotechnology
ICOS Corporation, a biotechnology company headquartered in Bothell, Washington, is dedicated to bringing innovative therapeutics to patients. Through Lilly ICOS LLC, ICOS is marketing its first product, Cialis® (tadalafil)(1), for the treatment of erectile dysfunction. ICOS is working to develop treatments for serious unmet medical needs such as benign prostatic hyperplasia, pulmonary arterial hypertension, cancer, psoriasis and inflammatory diseases. ( www.icos.com )

ICOS Corporation
22021 20Th Avenue SE
Bothell, Washington 98021
USA

Tel: (425) 485-1900
Fax: (425) 489-0356

Amersham plc

Industry: Pharmaceuticals, Biotechnology
Amersham is a world leader in medical diagnostics and in life sciences. We employ 9,500 people around the world. Our shares are traded on the London, New York and Oslo stock exchanges (AHM), and we are listed on the FTSE Index of Britain’s 100 largest companies. Our company was formed in 1997 from the businesses of Amersham International (UK), Pharmacia Biotech (Sweden) and Nycomed (Norway). In 2001 the company changed its name to Amersham plc and our businesses became Amersham Biosciences and Amersham Health. Together we combine skills in understanding genetic predisposition and the molecular basis of disease, with those for screening for ( www.amersham.com )

Amersham plc
Amersham Place
Little Chalfont, Buckinghamshire HP7 9NA
United Kingdom

Tel: +44 1494 544000
Fax: +44 1494 542266

Baxter Healthcare Corporation

Industry: Medical Equipment, Pharmaceuticals, Biotechnology
Baxter Healthcare Ltd. is the primary domestic operating subsidiary of Baxter International Inc. (NYSE: BAX). Baxter International Inc., through its subsidiaries, assists health-care professionals and their patients with treatment of complex medical conditions, including cancer, haemophilia, immune disorders, kidney disease and trauma. The company applies its expertise in medical devices, pharmaceuticals and biotechnology to make a meaningful difference in patients’ lives. Baxter is a trademark of Baxter International Inc. ( www.baxterhealthcare.com.au )

Baxter Healthcare Corporation
Route 120 And Wilson Road
Round Lake, Illinois 60073
USA

Tel: (847) 948-4770
Fax: (847) 270-2422